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Tofacitinib is used alone or together with other medicines (eg, DMARDs) to treat moderate to severely active rheumatoid arthritis, active psoriatic arthritis, ulcerative colitis, ankylosing spondylitis, and polyarticular course juvenile idiopathic arthritis (pcJIA) in patients who have taken other medicines (eg, methotrexate) that did not work well.
Tofacitinib is a Janus kinase (JAK) inhibitor that works on the immune system.
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms:
Tablet
Tablet, Extended Release
Solution
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Before Using
In deciding to use a medicine, the risks of taking the Tofacitinib 5 mg (Tofacent) medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Appropriate studies have not been performed on the relationship of age to the effects of tofacitinib extended-release tablet in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tofacitinib tablet and oral liquid in children 2 to 17 years of age with pcJIA. Safety and efficacy have been established.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tofacitinib in the elderly. However, elderly patients are more likely to have serious infections, which may require caution in patients receiving tofacitinib.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Abatacept
Adenovirus Vaccine Type 4, Live
Adenovirus Vaccine Type 7, Live
Anifrolumab-fnia
Apalutamide
Avacopan
Azathioprine
Bacillus of Calmette and Guerin Vaccine, Live
Carbamazepine
Cholera Vaccine, Live
Cyclosporine
Dengue Tetravalent Vaccine, Live
Enzalutamide
Fluconazole
Fosphenytoin
Infliximab
Influenza Virus Vaccine, Live
Lumacaftor
Mavacamten
Measles Virus Vaccine, Live
Mitotane
Mumps Virus Vaccine, Live
Phenytoin
Poliovirus Vaccine, Live
Rifampin
Rotavirus Vaccine, Live
Rubella Virus Vaccine, Live
Ruxolitinib
Smallpox Vaccine
St John's Wort
Tacrolimus
Tazemetostat
Typhoid Vaccine, Live
Varicella Virus Vaccine, Live
Yellow Fever Vaccine
Zoster Vaccine, Live
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
Anemia (blood disease) or
Hyperlipidemia (high cholesterol in the blood) or
Infection, history of or
Neutropenia (blood disease) or
Stomach or bowel problems (eg, blockage, diverticulitis, perforation, ulcers), history of—Use with caution. May make these conditions worse.
Diabetes or
Lung disease (eg, interstitial lung disease), or history of or
Lymphopenia (blood disease)—Use with caution. May increase risk of developing infections.
Heart or blood vessel disease or
Hepatitis B, history of or
Hepatitis C, history of or
Herpes zoster infection or
Tuberculosis, active or history of or
Weakened immune system—May cause side effects to become worse.
Infection, active or
Liver disease, severe—Use is not recommended in patients with these conditions.
Kidney disease (eg, patients on dialysis), moderate or severe or
Liver disease, moderate—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Smoker, current or past—May increase risk for serious side effects.
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发表于 2024-12-28 12:19:12